Mayo Clinic Talks COVID-19 Miniseries Episode 34: Multisystem Inflammatory Syndrome (MIS-C) in Pediatric Patients

Mayo Clinic Talks

Mayo Clinic Talks Podcast #169

COVID-19 Miniseries Episode 34: Multisystem Inflammatory Syndrome (MIS-C) in Pediatric Patients

Registration required for CME credit


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COVID-19 information evolves daily.  The views and perspectives shared in these resources are presented based on information available at the time of recording.
Recorded May, 2020

For the most up to date information visit:

CDC - Information for Healthcare Professionals about Coronavirus (COVID-19)
World Health Organization's Country & Technical Guidance - Coronavirus disease (COVID-19)
AskMayoExpert COVID-19 Navigator
COVID-19 Online Education, Resources and Updates

Guest: Nipunie S. Rajapakse, M.D., M.P.H.
Host: Amit K. Ghosh, M.D.

Patients under 21 who present with fever, lab evidence of inflammation, multisystem involvement, and recent or current SARS-CoV-2 infection fall under the case definition for multisystem inflammatory syndrome. They commonly present with persistent fever and gastrointestinal symptoms and concerningly, shock. Why are we seeing disproportionate rates in children of racial and ethnic minorities? Dr. Nipunie Rajapaske concisely covers what’s known about this syndrome and the data supporting its emergence as a post-infection complication.

CDC Health Advisory on Multisystem Inflammatory Syndrome in Children (MIS-C)

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study


Target Audience

This course is intended for primary care providers: physicians, nurse practitioners, and physician assistants

Learning Objectives

Upon completion of the Mayo Clinic Talks Podcast episode, learners should be able to:

  • Recall laboratory markers of inflammation and their role in diagnosis of multisystem inflammatory syndrome
  • Recall the case definition of multisystem inflammatory disease and how it differs from Kawasaki disease and Toxic Shock Syndrome
  • Recall the disproportionate prevalence of multisystem inflammatory disease in children of racial and ethnic minorities
  • Recall the data supporting multisystem inflammatory disease being a post-infection complication rather than a direct viral injury


Participation in this Mayo Clinic online course does not indicate nor guarantee competence or proficiency in the performance of any procedures which may be discussed or taught in this course.

Course summary
Available credit: 
  • 0.25 AMA PRA Category 1 Credit
  • 0.25 Attendance
Course opens: 
Course expires: 

Accreditation Statement
In support of improving patient care, Mayo Clinic College of Medicine and Science is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Credit Statement(s):


Mayo Clinic College of Medicine and Science designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

For disclosure information regarding Mayo Clinic School of Continuous Professional Development accreditation review committee member(s), please go here to review disclosures.

Available Credit

  • 0.25 AMA PRA Category 1 Credit
  • 0.25 Attendance


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