Neuroendocrine Dysfunction in Pediatric Mood Disorders

Manpreet K. Singh, MD, MS

Introduction
 

Dr. Singh is an Assistant Professor of Psychiatry and Behavioral Sciences, and passionately engages in the clinical, research, and teaching missions in the Department of Psychiatry.  Her goal is to accelerate understanding and treatment in youth with or at high risk for developing lifelong mood disorders. She believes that if it is predictable, it is preventable.  That is, if we can identify symptoms early in life, we can prevent them from progressing to more disabling chronic conditions.

Dr. Singh earned her MD at Michigan State University and her MS at University of Michigan.  She completed her combined residency training in Pediatrics, Psychiatry, and Child and Adolescent Psychiatry at Cincinnati Children’s Hospital Medical Center. After two years of postdoctoral training at Stanford, she joined our faculty in 2009. 

Dr. Singh leads a multidisciplinary team that evaluates and treats youth with a spectrum of mood disorders as young as age 2 and well into their 20s. Her research investigates the origins and pathways for developing mood disorders during childhood, as well as discovering methods to protect and preserve function after symptoms begin. After completing her National Institute of Mental Health career development award that characterized emotion regulation in healthy offspring of parents with bipolar disorder, she was endowed with a Faculty Scholar Award in Pediatric Translational Medicine. Now, she is leading three independent NIMH funded studies examining mechanisms underlying mood disorders and their treatment.

In the service of preventing mood disorders from sticking around for a lifetime, Dr. Singh’s research portfolio is broad and deep, with exceptional potential for returns in investment. She is examining the benefits and the risks to the developing brain of medications for mood problems.  She is using cutting edge strategies to directly modulate the brain using transcranial magnetic stimulation and real time neurofeedback.  She is investigating the benefits of psychotherapies, such as family focused psychotherapy, and mindfulness meditation to reduce mood symptoms and family stress.  All of these areas of research hold considerable promise to impact our understanding of the core mechanisms underlying mood disorders and how treatment early in life can pave the path to more adaptive outcomes.

Learning Objectives

1. Recognize that youth with depression and obesity may show early signs of neuroendocrine dysfunction
2. Demonstrate neural and behavioral characteristics of approach motivation in pedicatric mood disorders
3. Consider candidate targets in the brain reward system for intervention

Live webcast available at: http://videos.mayo.edu/live
1 AMA PRA Category 1 Credit(s)™ hour is offered for watching this Webcast live. Ethos will be implemented for all post presentation surveys. To document your attendance, please text the code given at the presentation to 507-200-3010. For questions, email rstpsychgr@mayo.edu.

Accreditation Statement

In support of improving patient care, Mayo Clinic College of Medicine and Science is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Credit Statement(s)

AMA
Mayo Clinic College of Medicine and Science designates this live activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

APA
The Department of Psychiatry and Psychology at Mayo Clinic, Rochester, is approved by the American Psychological Association to sponsor continuing education credits for psychologists. The Department of Psychiatry and Psychology at Mayo Clinic, Rochester maintains responsibility for this program and its content.

Archived webcast available at: Psychiatry & Psychology Video Library

Industry Acknowledgment (if applicable): None.

All participants MUST complete the evaluation in order to get CME or APA Credit.

1) Text the CODE announced at the session within 48 hours to (507) 200-3010
2) Login at ce.mayo.edu and go to My Account, My Courses, Registered Courses, click Session title and START to access the required Evaluation.
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Click the START button on that session page.
3) Evaluation must be completed within 2 weeks.

Disclosure Summary
As a Jointly Accredited Provider by ACCME, ACPE, and ANCC, Mayo Clinic College of Medicine and Science must ensure balance, independence, objectivity and scientific rigor in its educational activities. Course Director(s), Planning Committee Members, Faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty also will disclose any off label and/or investigational use of pharmaceuticals or instruments discussed in their presentation. Disclosure of these relevant financial relationships will be published in activity materials so those participants in the activity may formulate their own judgments regarding the presentation.

Listed below are individuals with control of the content of this program who have disclosed…

Relevant financial relationship(s) with industry:

Mark Frye, M.D. - Mayo Clinic

Grant Support: AssureRx, Janssen R&D, Myriad, Pfizer Consultant: Janssen R&D, Mitsubishi Tanabe Pharma Corp., Myriad Genetics, Sunovion, Supernus Pharmaceuticals, Teva Pharmaceuticals, Neuralstem, Inc.

CME/Travel: American Physician Institute, CME Outfitters

Manpreet Singh, M.D., M.S.

Grant Support:  National Institute of Mental Health, National Institute on Aging, Brain and Behavbior Foundation, Neuronetics, Johnson and Johnson
Advisory Board: Sunovion

No relevant financial relationship(s) with industry:
Kriti Gandhi, M.D., Allison Holgerson, Ph.D., Matej Markota, M.D., Charlene Nelson, Reem Shafi, M.B.B.S., Larua Suarez, M.D.

References to off-label usage(s) of pharmaceuticals or instruments in their presentation:

NONE