Pharmacy Grand Rounds 
Red or Blue: Which One for You? Hydroxocobalamin or Methylene Blue for Refractory Vasoplegic Shock

• ACPE Universal Activity Number (UAN): JA0000238-0000-21-004-L01-P
• Session Type: Knowledge-based
• CE Credits: A maximum of 0.75 contact hour (0.075 CEU) for the following: 
  • AAPA Category 1 CME Credits
  • ACPE
  • AMA PRA Category 1 Credits™
  • ANCC

• Session Fee: Free for Mayo Clinic staff

SESSION LOCATIONS

Live Session: (11:00am - 11:45am CST) 

Until further notice, learners must watch Pharmacy Grand Rounds live via the web by going to the Video Exchange and selecting “Pharmacy Grand Rounds” in the “Streaming Now” section.

Participants may attend by viewing: Live Webcast
Video Recording - access two weeks after session date

COURSE DESCRIPTION

Refractory vasoplegic shock is a complication of cardiac surgery and a concerning problem with an incidence of 20-30%. Vasoplegia is a physiologic state defined by low systemic vascular resistance and blood pressure in the presence of normal to increased cardiac output. Vasoplegia can be present in different scenarios including cardiac surgery, sepsis, and anaphylaxis. Currently there is no standard of care for treatment of refractory vasoplegic shock, and it is associated with poor outcomes. This presentation will review the current treatment pathways of refractory vasoplegic shock with off-label use of available medications.

LEARNING OBJECTIVES
At the conclusion of this knowledge-based CE session, participants should be able to:

• Describe the pathophysiology of refractory vasoplegic shock
• Examine literature detailing use of methylene blue and hydroxocobalamin for refractory vasoplegic shock
• Identify appropriate use of methylene blue or hydroxocobalamin in refractory vasoplegic shock

Session Announcement

PowerPoint

FACULTY INFORMATION

Courtney T. Matthews, PharmD
PGY1 Pharmacy Resident
Mayo Clinic Health System- Eau Claire, WI

Courtney received a Doctor of Pharmacy degree from University of Minnesota- Twin Cities. She is a current PGY1 at Mayo Clinic Health System- Eau Claire Hospital with practice interests in critical care, emergency medicine, and infectious diseases.

DISCLOSURE STATEMENTS
As a provider accredited by Joint Accreditation Interprofessional Continuing Education, Mayo Clinic College of Medicine and Science (Mayo Clinic School of CPD) must ensure balance, independence, objectivity and scientific rigor in its educational activities. Course Director(s), Planning Committee Members, Faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty also will disclose any off label and/or investigational use of pharmaceuticals or instruments discussed in their presentation. Disclosure of these relevant financial relationships will be published in activity materials so those participants in the activity may formulate their own judgments regarding the presentation.

Listed below are individuals with control of the content of this program:

The faculty report the following relationships:

• Courtney L. Matthews, PharmD
  • Declares no financial relationship(s) pertinent to this session
  • Declares off-label use of devices and medications will be discussed during this presentation, including:
    • Hydroxycobalamin
    • Methylene blue

Course Director and Planning Committee Members declare no relevant financial relationship(s) pertinent to this session. 

Members include:

• Jennifer Elmer, DNP, APRM, CCNS, FCCM
• Michael Huckabee, MPAS, PA-C, PhD
• Sarah Jane Kotval, BSW
• Wayne (Nick) Nicholson, MD, PharmD, BCPS
• Garrett Schramm, PharmD, BCPS
• Lee Skrupky, PharmD, BCPS
• Brenda Stellmaker