Toward Practical Application of Pharmacogenomics and AI:  Major Depression as a Case Study
William Bobo, M.D., M.P.H. and Arjun Athreya, Ph.D., M.S.

William Bobo, MD, MPH, is Professor and Chair, Department of Psychiatry & Psychology, at Mayo Florida. His research is focused on epidemiological investigations of mood disorders and treatment in adults and the prediction of treatment outcomes in adults with unipolar and bipolar depression. His research has been supported by NIMH, AHRQ, NSF, the Myocarditis Foundation, and the Mayo Foundation for Medical Education and Research.

Arjun Athreya, PhD, MS, is an Assistant Professor at Mayo Clinic's Department of Molecular Pharmacology and Experimental Therapeutics. He earned his MS degrees in Electrical and Computer Engineering and Computer Science from Carnegie Mellon University, and PhD in Electrical and Computer Engineering from Univ. of Illinois at Urbana-Champaign.

Through close collaborations with physicians, his core research focuses on innovations in computer systems engineering, and artificial intelligence based technologies for individualizing medicine. ALMOND -- Analytics and Machine Learning for Omics and Clinical Data, is an analytical framework that was developed as part of his doctoral dissertation.

Dr. Athreya was an inaugural Fellow of the Mayo Clinic-Illinois Alliance for Technology-Based Healthcare research, and a Fellow of National Center for Supercomputing Applications at Univ. of Illinois. Facets of his doctoral research have received honors from both engineering and healthcare/life-science science communities, including Rambus Award for Excellence in Computer Engineering at Illinois, and Presidential Trainee Awards (2017-2019) and the Jason Morrow Award from the American Society for Clinical Pharmacology and Therapeutics. Dr. Athreya’s research is funded by NSF, NIH and Mayo Medical Foundation.

Learning Objectives
Upon conclusion of this activity, participants should be able to:

• Describe the phenotype complexities that make reliable outcome prediction in the treatment of adults with major depression difficult to achieve.
• Discuss an approach that integrates AI and pharmacogenomics as an initial step toward improving the prediction of response to antidepressants in adults with major depression.
• Explore how similar approaches can be used to inform future-omics investigations for predicting response to antidepressants in adults with major depression.

1 AMA PRA Category 1 Credit(s)™ hour is offered for watching this presentation via Zoom.  Ethos will be implemented for all post presentation surveys.  To document your attendance, please text the code given at the presentation to 507-200-3010.  For questions, email rstpsychgr@mayo.edu

Accreditation Statement
In support of improving patient care, Mayo Clinic College of Medicine and Science is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Credit Statement(s)

AMA
Mayo Clinic College of Medicine and Science designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

 
 

APA
Continuing Education (CE) credits for psychologists are provided through the co-sponsorship of the American Psychological Association (APA) Office of Continuing Education in Psychology (CEP).  The APA CEP Office maintains responsibility for the contents of the programs. 

This activity is approved for a maximum of 1.00 credits.  Credit is awarded only for actual instructional time.

All participants MUST complete the evaluation in order to get CME or APA Credit.

1) Text the CODE announced at the session within 48 hours to (507) 200-3010
2) Login at ce.mayo.edu and go to My Account, My Courses, Registered Courses, click Session title and START to access the required Evaluation.

-or-

Click the START button on that session page.

3) Evaluation must be completed within 2 weeks.

Disclosure Summary
As a provider accredited by Joint Accreditation Interprofessional Continuing Education, Mayo Clinic College of Medicine and Science (Mayo Clinic School of CPD) must ensure balance, independence, objectivity and scientific rigor in its educational activities. Course Director(s), Planning Committee Members, Faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity.  Safeguards against commercial bias have been put in place.  Faculty also will disclose any off label and/or investigational use of pharmaceuticals or instruments discussed in their presentation.  Disclosure of these relevant financial relationships will be published in activity materials so those participants in the activity may formulate their own judgments regarding the presentation.

Listed below are individuals with control of the content of this program who have disclosed…

Relevant financial relationship(s) with industry:
William Bobo:  Research Support: NSF, NIGMS, NIMH, DoD, AHRQ, Myocarditis Foundation, and the Mayo Foundation for Medical Education and Research

Arjun Athreya:  Research Support: NSF, and the Mayo Foundation for Medical Education and Research

No relevant financial relationship(s) with industry: 
Olivia Bogucki, PhD, Rana Elmaghraby, MD, Bhanu Kolla, MD, Charlene Nelson (coordinator), Amber Pearson (coordinator), Lauren Phillips, MD

References to off-label usage(s) of pharmaceuticals or instruments in their presentation:
None

For disclosure information regarding Mayo Clinic School of Continuous Professional Development accreditation review committee member(s), please go here. 

ATTENDANCE / CREDIT
Text the session code (provided only at the session) to 507-200-3010 within 48 hours of the live presentation to record attendance. All learners are encouraged to text attendance regardless of credit needs. This number is only used for receiving text messages related to tracking attendance. Additional tasks to obtain credit may be required based on the specific activity requirements and will be announced accordingly. Swiping your badge will not provide credit; that process is only applicable to meet GME requirements for Residents & Fellows.

TRANSCRIPT
Any credit or attendance awarded from this session will appear on your Transcript.

For disclosure information regarding Mayo Clinic School of Continuous Professional Development accreditation review committee member(s) and staff, please go here to review disclosures.