Session date: 
12/10/2015 - 8:00am to 9:00am

Phase I/IB Study of Azacitidine and Hedgehog Pathway Inhibition in Myeloid Malignancies 

Learning Objectives:

  • Identification of preclinical with azacitidine combination.
  • Response rates and side effect of combining azacitidine with sonidegib (LDE225).
Raoul Tibes, MD, PhD
Consultant & Director Acute and Chronic Leukemia Program
Division of Hematology & Medical Oncology
Scholar in Clinical Research, Leukemia and Lymphoma Society
Assistant Professor, Mayo College of Medicine
Mayo Clinic/Mayo Clinic Cancer Center  
Phoenix, Arizona
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Anti-tumor phagocytic cell activation in multiple myeloma by the IAP antagonist LCL161: Results of a Phase II clinical trial 

Learning Objectives:

  • Describe the role of innate immunity in myeloma growth control.
  • Understand how drug therapy can modulate immune response.
Leif Bergsagel, MD
Professor of Medicine
David F. and Margaret T. Grohne Professor of Novel Therapeutics for Cancer Research
Mayo Clinic 
Phoenix, Arizona
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LOCATION  Scottsdale Campus:  TAYLOR AUDITORIUM and Phoenix Campus:  MCH 1-212
 
* * NEW ATTENDANCE REQUIREMENT * *
A unique presentation code must be sent via text to 507-200-3010 
to record attendance and to ensure you receive CME credit for your attendance.  
NOTE:  Attendees must be present to receive code.
 
ABOUT Cancer Center Grand Rounds are held weekly on Thursdays for faculty and junior faculty, investigators and junior investigators, scholars, graduate students, medical students, research fellows, administration and allied health staff.
 
ACCREDITATION  Mayo Clinic College of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians  Mayo Clinic College of Medicine designates this live activity for a maximum of 1 AMA PRA Category 1 Credit(s) TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Allied health professionals should contact their licensing board for licensure/certification requirements. 

Mayo Clinic College of Medicine adheres to all ACCME standards regarding commercial support of continuing medical education and attests to the fact that this enduring material was produced in compliance with ACCME essentials. No commercial support was received in the production of this CME activity. 

FACULTY DISCLOSURE  As a provider accredited by Accreditation Council on Continuing Medical Education (ACCME), Mayo Clinic College of Medicine, must ensure balance, independence, objectivity and scientific rigor in its educational activities. Course director(s), planning committee, faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty also disclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentation. Disclosure of these relevant financial relationships is included course materials so participants may formulate their own judgments regarding the presentation.

ADDITIONAL INFORMATION Light refreshments will be served. 

ARCHIVED PRESENTATIONS Located in Arizona Cancer Center Grand Rounds video library at http://videoexchange.mayo.edu.

Where did the idea for the course originate?: 
Arizona
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Where did the idea for the course originate?: 
Arizona