PRESENTATION TITLE
PD-1 Blockade in Mismatch Repair Deficient Tumors
PRESENTER(S)
Luis Alberto Diaz, Jr., M.D.
Head of the Division of Solid Tumor Oncology; Grayer Family Chair, Memorial Sloan Kettering Cancer Center, New York, NY

PRESENTER BIO

Dr. Luis Diaz is an internationally recognized physician-scientist with a special interest in cancer genetics and immuno-oncology. His work has involved the clinical development of tumor-derived DNA as a biomarker for cancer screening, early detection, monitoring, and the measurement of early residual disease.

He has pioneered several diagnostic and therapeutic genomic approaches to cancer, and he specializes in the treatment of pancreatic and colorectal cancers. With colleagues, he developed the basis for a molecular Pap smear, a promising way to detect early-stage ovarian and endometrial cancers based on genetic markers. He has also harnessed the power of cancer mutations as potent antigens and championed the use of checkpoint inhibitors in the treatment of patients with tumors that have exceptionally high mutational burdens. In addition, his landmark proof-of-principle study using PD-1 blockade in patients with mismatch repair deficiency showed dramatic responses in patients who had failed standard therapy, resulting in a breakthrough status designation by the FDA. 

Dr. Diaz received his undergraduate and medical degrees from the University of Michigan. He completed his residency training at the Osler Medical Service at Johns Hopkins and medical oncology training at the Johns Hopkins Kimmel Cancer Center.

At Johns Hopkins, Dr. Diaz was the Director of the Swim Across America Laboratory and a member of the Ludwig Center for Cancer Genetics and Therapeutics, as well as a member of the groups that received the 2013 AACR Team Cancer Award for Pancreatic Cancer Sequencing, the 2014 Team Cancer Award for Malignant Brain Tumors, and the 2017 Team Cancer Award for the development of Liquid Biopsies in Cancer. Also in 2017, his team was awarded the Team Cancer Award for Colorectal Cancer. Dr. Diaz will spearhead Stand Up To Cancer’s (SU2C) Colorectal Cancer Dream Team, which has received up to $12 million in funding from SU2C. The announcement was made at a special event during the 2017 Annual Meeting of the American Association for Cancer Research (AACR).

VIEWING LOCATIONS
Virtually via Zoom

LEARNING OBJECTIVES

• Recognize the immunogenicity of Mismatch Repair Deficient Tumors.
• Identify the therapeutic options for Mismatch Repair Deficient Tumors.
• Review the future developments of Mismatch Repair Deficient Tumors.

ATTENDANCE / CREDIT
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TRANSCRIPT
Any credit or attendance awarded from this session will appear on your Transcript.

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