Mayo Clinic Talks COVID-19 Miniseries Episode 32: The Fierce Urgency of Now - Pursuing a Safe and Efficacious Vaccine

Mayo Clinic Talks

Mayo Clinic Talks Podcast #167

COVID-19 Miniseries Episode 32: The Fierce Urgency of Now - Pursuing a Safe and Efficacious Vaccine

Registration required for CME credit


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COVID-19 information evolves daily.  The views and perspectives shared in these resources are presented based on information available at the time of recording.
Recorded May, 2020

For the most up to date information visit:

CDC - Information for Healthcare Professionals about Coronavirus (COVID-19)
World Health Organization's Country & Technical Guidance - Coronavirus disease (COVID-19)
AskMayoExpert COVID-19 Navigator
COVID-19 Online Education, Resources and Updates

Guest: Gregory A. Poland, M.D. @drgregpolandHost: Amit K. Ghosh, M.D., M.B.A. @AmitGhosh006

SARS-CoV-2, as an RNA virus, has marked capacity for mutation and recombination events. How do we build an efficacious and safe vaccine against it? How could we safely speed up development? Is a vaccine neutralizing the spike protein enough? Dr. Greg Poland returns to give you an update from the front lines of research on vaccine development and ongoing clinical trials.

AskMayoExpert COVID-19 Resources:

Connect with the Mayo Clinic’s School of Continuous Professional Development online at or on Twitter @MayoMedEd.


Target Audience

This course is intended for primary care providers: physicians, nurse practitioners, and physician assistants

Learning Objectives

Upon completion of this Mayo Clinic Talks Podcast episode, learners should be able to:

  • Recall vaccines should be efficacious, safe, and scalable for manufacturing and administration.
  • Recall variety of targets for holistic development of immunity to SARS-CoV-2
  • Recall the role and risks of a neutralizing antibody
  • Recall the importance of T-helper cell activation in adaptive and cellular immunity and viral clearance
  • Summarize the risks of human challenge studies and their potential role in speeding up vaccine development


Participation in this Mayo Clinic online course does not indicate nor guarantee competence or proficiency in the performance of any procedures which may be discussed or taught in this course.

Course summary
Available credit: 
  • 0.75 AMA PRA Category 1 Credit
  • 0.75 Attendance
Course opens: 
Course expires: 


For disclosure information regarding Mayo Clinic School of Continuous Professional Development accreditation review committee member(s), please go here to review disclosures.

Available Credit

  • 0.75 AMA PRA Category 1 Credit
  • 0.75 Attendance


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