Mayo Clinic Proceedings - Symposium on Neurosciences - Idiopathic REM Sleep Behavior Disorder: Diagnosis, Clinical Implications, and Future Directions (November 1, 2017)

One of the premier peer-reviewed clinical journals in general and internal medicine, Mayo Clinic Proceedings is among the most widely read and highly cited scientific publications for physicians, with a circulation of approximately 125,000. Mayo Clinic Proceedings is published by Elsevier and sponsored by Mayo Clinic and the Mayo Foundation for Medical Education and Research. The mission of Mayo Clinic Proceedings is to promote the best interest of patients by advancing the knowledge and professionalism of the physician community. Since 2009 the Journal has offered CME credit for specific articles from both the Mayo Clinic for Concise Review for Clinicians and specially commissioned Symposia articles (comprehensive coverage on one topic).  

Participation in this activity consists of reviewing articles and responding to a short online test. It is estimated that this activity will take approximately one hour per article.  There is no charge for participating in this Journal CME activity.

To receive CME credit, please do the following:

  • Click Take Course
  • Complete quiz and evaluation (There is a required 80% pass rate in order to earn credit, with 1 retake allowed.)
  • Print your Record of Attendance


Target Audience

The target audience for Mayo Clinic Proceedings is primarily internal medicine physicians and other clinicians who wish to advance their current knowledge of clinical medicine and who wish to stay abreast of advances in medical research.

Learning Objectives

 On completion of this article, you should be able to: (1) recognize rapid eye movement (REM) sleep behavior disorder (RBD), a potentially injurious parasomnia that is strongly associated with synucleinopathy neurodegeneration; (2) understand the pathophysiology of RBD; (3) delineate idiopathic and symptomatic etiologies for RBD; and (4) choose efficacious and tolerable treatments for RBD.

Course summary
Available credit: 
  • 1.00 ABIM
  • 1.00 AMA PRA Category 1 Credit
Course opens: 
Course expires: 


No relevant financial relationships:

Planning Committee, Editorial Board Members and Staff
Thomas J. Beckman, M.D.
Timothy B. Curry, M.D., Ph.D.
William L. Lanier, Jr., M.D.
Terry Jopke
Eric L. Matteson, M.D.
Karl A. Nath, M.D.
S. Vincent Rajkumar, M.D.
Kimberly D. Sankey
Nicki Smith
A. Keith Stewart, M.D.
Margaret (Peg) Wentz
Christopher M. Wittich, M.D.

Relevant financial relationships: 

Editorial Board:  Michelle Mauermann, M.D. - Consultant - IONIS Pharmaceuticals, Honoraria - Continuum

Off-label drugs:  None.


Authors:  Erik K. St Louis, MD, MS, and Bradley F. Boeve, MD

Affiliations: Center for Sleep Medicine and Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN.

Conflicts of Interest: Dr St. Louis receives research support from Mayo Clinic CCaTS, NIH/NHLBI, and Sunovion and book royalties from Wiley-Blackwell for Epilepsy and the Interictal State: Co-morbidities and Quality of Life. Dr Boeve reports that he is an investigator in clinical trials sponsored by Cephalon, Allon Pharmaceuticals, and GE Healthcare. He receives royalties from the publication of a book titled The Behavioral Neurology of Dementia (Cambridge Medicine) (2009). He has received honoraria from the American Academy of Neurology. He receives research support from the National Institute on Aging (grant nos. P50 AG16574 [coinvestigator], U01 AG06786 [coinvestigator], RO1 AG32306 [coinvestigator]) and the Mangurian Foundation.

Grant Support: The work was supported by Clinical and Translational Science Awards grant UL1 TR000135 from the National Center for Advancing Translational Science (NCATS). Dr Boeve’s support relevant to this work includes grants P50 AG016574, UO1 AG006786, and RO1 AG015866, the Mayo Clinic Dorothy and Harry T. Mangurian Jr. Lewy Body Dementia Program, and the Little Family Foundation.

Off-label drugs:  Any therapy for REM sleep behavior disorder (chiefly, melatonin and clonazepam).

Accreditation Statement:

In support of improving patient care, Mayo Clinic College of Medicine and Science is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.


Credit Statement(s):


Mayo Clinic College of Medicine and Science designates this Journal-based CME activity for a maximum of 1.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity enables the participant to earn up to 1 MOC point in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC points.

Other Healthcare Professionals

A certificate of attendance will be provided to other healthcare professionals for requesting credits in accordance with state nursing boards, specialty societies, or other professional associations.

For disclosure information regarding Mayo Clinic School of Continuous Professional Development accreditation review committee member(s), please go here.

Available Credit

  • 1.00 ABIM
  • 1.00 AMA PRA Category 1 Credit

Accreditation Period

Course opens: 
Course expires: 
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