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Behavioral Neurology
David Knopman, M.D.
"Beta Amyloid and Tau Biology as Revealed by PET Imaging"

Learning objectives:

• Describe the temporal and regional pattern of amyloid and accumulation in the brain
• Describe the temporal and regional pattern of neurofibrillary tangle tau accumulation in the brain
• Describe the interrelationship between amyloid and tau as it relates to the pathogenesis of Alzheimer disease

The presenter (and/or spouse/partner) has the following relevant financial relationship to disclose: Grant/research support - Biogen, Lilly; Other - Dr. Knopman served on a Data Safety Monitoring Board for the DIAN study. He serves on a Data Safety monitoring Board for a tau therapeutic for Biogen but receives no personal compensation. He is a site investigator in the Biogen aducanumab trials discussed here. He is an investigator in clinical trials sponsored by Lilly Pharmaceuticals and the University of Southern California. He serves as a consultant for Samus Therapeutics, Third Rock, Roche and Alzeca Biosciences but receives no personal compensation. He receives research support from the NIH. The presenter does not intend to discuss an off-label/investigative use of a commercial product/device.

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TRANSCRIPT
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