Advanced ECG Interpretation Online CNE Course

This online CNE course includes nine online modules designed to prepare nurses and healthcare professionals for recognizing normal and subsequent changes on a 12-lead ECG associated with ischemia, injury, infarction, bundle branch blocks, and hypertrophy. The modules also include recognition of axis deviation along with differentiation of ectopy from aberrancy, assessment of QT intervals, and clinical significance. Emphasis is placed on the pathophysiology of these changes, clinical presentation, and interventions for all. It is strongly recommended to have prior knowledge of basic ECG interpretation before completing these modules. 


Mayo Clinic learners-search for this course in the internal LMS system My Learning for registration. Course name is Advanced ECG interpretation, ID# A1060210ECIN21).


Target Audience

This online CNE course is designed for nurses and other healthcare professionals providing care for patients requiring 12-lead ECG interpretation.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Explain fundamental principles of advanced ECG interpretation
  • Identify clinical significance for changes on a 12-lead ECG
  • Describe interventions associated with changes on a 12-lead ECG
  • Identify life-threatening changes on a 12-lead ECG

Attendance at any Mayo Clinic course does not indicate or guarantee competence or proficiency in the skills, knowledge or performance of any care or procedure(s) which may be discussed or taught in this course.

Course summary
Available credit: 
  • 4.50 ANCC
  • 4.50 Attendance
Course opens: 
Course expires: 

This course will be presented via self-guided interactive modules.

Jennifer M. McGuire, MAN, RN, NPD-BC
Nursing Education Specialist Manager
Department of Nursing
Instructor in Nursing, Mayo Clinic College of Medicine and Science
Mayo Clinic, Rochester, MN

Course Director
Denise Rismeyer, MSN, RN, NPD-BC
Nursing Education Specialist-Continuing Nursing Education Program
Assistant Professor of Nursing, Mayo Clinic College of Medicine and Science
Department of Nursing
Mayo Clinic, Rochester, MN

Accreditation Statement
In support of improving patient care, Mayo Clinic College of Medicine and Science is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.


Credit Statements


Mayo Clinic College of Medicine and Science designates this activity for a maximum of 4.50 ANCC contact hours.

Other Healthcare Professionals

A record of attendance will be provided to all registrants for requesting credits in accordance with state nursing boards, specialty societies or other professional associations.

Available Credit

  • 4.50 ANCC
  • 4.50 Attendance


Please login or register to take this course.

Cancellation and Refund Policy:

Request for cancellations must be submitted in writing to


Any use of this site constitutes your agreement to the Terms and Conditions of Online Registration.

If you are interested in purchasing a license for reuse of this education within your organization, contact for more information.

Required Hardware/software

Audio and video capability is required for optimal participation in this online course.