Pharmacy Grand Rounds
Don’t be Salty: Non-inotropic Strategies to Overcome Loop Diuretic Resistance in Acute Decompensated Heart Failure

• ACPE Universal Activity Number (UAN): JA0000238-0000-20-028-L01-P
• Session Type: Knowledge-based
• CE Credits: A maximum of 0.75 contact hour (0.075 CEU) for the following: 
  • AAPA Category 1 CME Credits
  • ACPE
  • AMA PRA Category 1 Credits™
  • ANCC

• Session Fee: Free for Mayo Clinic staff

SESSION LOCATIONS

Live Session: (11:00am - 11:45am CST)

Until future notice, learners must watch Pharmacy Grand Rounds live via the web by going to the Video Exchange and selecting “Pharmacy Grand Rounds” in the “Streaming Now” section.

Participants may attend by viewing: Live Webcast
Video Recording - access two weeks after session date

COURSE DESCRIPTION

The American Heart Association estimates that approximately 6.5 million people in the United States have heart failure with more than 1 million hospitalizations annually for acute decompensated heart failure (ADHF). Often patients with heart failure are admitted for congestion and volume overload, which is treated with loop diuretics. Patients may develop loop diuretic resistance over time leading to difficulties treating ADHF and obtaining euvolemia. This presentation will review new evidence of non-inotropic strategies to overcomer loop diuretic resistance and describe potential ways to incorporate this evidence into clinical decision making.

At the conclusion of this knowledge-based CE session, participants should be able to:

1. Describe the pathophysiology of intravascular versus tissue congestion in ADHF
2. Explain the mechanisms of diuretic resistance in ADHF and why non-inotropic strategies may help augment diuresis
3. Discuss the literature on non-inotropic strategies to decongest patients and overcome loop diuretic resistance in ADHF

Session Announcement

Session Slides

FACULTY INFORMATION

Lindsay N. Moreland-Head, PharmD
Clinical Pharmacist
Mayo Clinic Hospital - Rochester, MN

Lindsay received a Doctor of Pharmacy degree from Purdue University in West Lafayette, IN.  She completed a PGY1 Pharmacy Residency and PGY2 Cardiology Residency at UPMC Presbyterian in Pittsburgh, PA. She is currently practicing at Mayo Clinic Hospital – Rochester with interests in advanced heart failure and left ventricular assist devices.

DISCLOSURE STATEMENTS

As a provider accredited by Joint Accreditation Interprofessional Continuing Education, Mayo Clinic College of Medicine and Science (Mayo Clinic School of CPD) must ensure balance, independence, objectivity and scientific rigor in its educational activities. Course Director(s), Planning Committee Members, Faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty also will disclose any off label and/or investigational use of pharmaceuticals or instruments discussed in their presentation. Disclosure of these relevant financial relationships will be published in activity materials so those participants in the activity may formulate their own judgments regarding the presentation.

Listed below are individuals with control of the content of this program:

The faculty report the following relationships:

• Lindsay N. Moreland-Head, PharmD
  • Declares no financial relationships pertinent to this session
  • Declares off-label use of devices and medications will not be discussed during this presentation.

Course Director and Planning Committee Members declare no relevant financial relationship(s) pertinent to this session.  Members include:

• Brenda Amaris
• Mary Ellen Cordes, MS, APRN, CNC, NE-BC
• Michael Huckabee, MPAS, PA-C, PhD
• Wayne (Nick) Nicholson, MD, PharmD, BCPS
• Garrett Schramm, PharmD, BCPS
• Lee Skrupky, PharmD, BCPS