Pharmacy Grand Rounds
Pharmacotherapy on MARS ® (Molecular Adsorbent Recirculating System)  

• ACPE Universal Activity Number (UAN): JA0000238-0000-20-028-L01-P
• Session Type: Knowledge-based
• CE Credits: A maximum of 0.75 contact hour (0.075 CEU) for the following: 
  • AAPA Category 1 CME Credits
  • ACPE
  • AMA PRA Category 1 Credits™
  • ANCC

• Session Fee: Free for Mayo Clinic staff

SESSION LOCATIONS

Live Session: (11:00am - 11:45am CST)

Until future notice, learners must watch Pharmacy Grand Rounds live via the web by going to the Video Exchange and selecting “Pharmacy Grand Rounds” in the “Streaming Now” section.

Participants may attend by viewing: Live Webcast
Video Recording - access two weeks after session date

COURSE DESCRIPTION

Liver failure, including acute and acute-on-chronic liver failure, is a substantial healthcare burden with mortality rates of up to 50%. Artificial liver dialysis has been implicated as a treatment modality for acute liver disease, in which, MARS ® (Molecular Adsorbent Recirculating System) is the most commonly used system. However, the benefit of MARS ® for patients with liver failure has not been well proven and conflicting evidence exists. This presentation will review the role of artificial liver dialysis in acute liver failure, describe the mechanism and indication of MARS, and discuss possible pharmacokinetic changes to medications affected by MARS.

At the conclusion of this knowledge-based CE session, participants should be able to:

1. Review the pathophysiology of acute liver failure and indications for liver dialysis
2. Describe the mechanism of MARS ® (Molecular Adsorbent Recirculating System)
3. Discuss pharmacokinetic changes of medication affected by MARS and clinically relevant implications

Session Announcement

Session Slides

FACULTY INFORMATION

Yen Tran, PharmD
PGY2 Solid Organ Transplant Pharmacy Resident
Mayo Clinic Hospital - Rochester, MN

Yen received a Doctor of Pharmacy degree from Nova Southeastern University in Fort Lauderdale, FL.  He completed a PGY1 Pharmacy Residency at AdventHealth Orlando, and is currently a PGY2 Solid Organ Transplant Pharmacy Resident at Mayo Clinic Hospital-Rochester. His practice interests include solid organ transplant, antibody mediated rejection, infection diseases in immunocompromised patients, immunotherapy, and pharmacy quality improvement.

DISCLOSURE STATEMENTS

As a provider accredited by Joint Accreditation Interprofessional Continuing Education, Mayo Clinic College of Medicine and Science (Mayo Clinic School of CPD) must ensure balance, independence, objectivity and scientific rigor in its educational activities. Course Director(s), Planning Committee Members, Faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty also will disclose any off label and/or investigational use of pharmaceuticals or instruments discussed in their presentation. Disclosure of these relevant financial relationships will be published in activity materials so those participants in the activity may formulate their own judgments regarding the presentation.

Listed below are individuals with control of the content of this program:

The faculty report the following relationships:

• Yen Tran, PharmD
  • Declares no financial relationships pertinent to this session
  • Declares off-label use of devices and medications will be discussed during this presentation, including:
    • MARS ® (Molecular Adsorbent Recirculating System)

Course Director and Planning Committee Members declare no relevant financial relationship(s) pertinent to this session.  Members include:

• Brenda Amaris
• Mary Ellen Cordes, MS, APRN, CNC, NE-BC
• Michael Huckabee, MPAS, PA-C, PhD
• Wayne (Nick) Nicholson, MD, PharmD, BCPS
• Garrett Schramm, PharmD, BCPS
• Lee Skrupky, PharmD, BCPS