Session date: 
12/09/2021 - 12:00pm to 1:00pm
PRESENTATION TITLE
Tapestry: Exome Sequencing for Clinical Practice & Research

PRESENTERS
Teresa M. Kruisselbrink, MS, CGC (Main Presenter)
Konstantinos N. Lazaridis, MD (Panel Presenter)
Matthew J. Ferber, PhD (Moderator)                                              

PRESENTERS BIO
Teresa M. Kruisselbrink, MS, CGC                                                                                                                                                                                           
Co-Director, Genomics in Action, Center for Individualized Medicine                                                                                                                                     
Certified Genetic Counselor                                                                                                                                                                                                         
Mayo Clinic, Rochester

Konstantinos N. Lazaridis, MD                                                                                                                                                                                                                                                                                                                                                                                                                                                 
Carlson and Nelson Endowed Executive Director, Center for Individualized Medicine 
Consultant, Gastroenterology         
Mayo Clinic, Rochester

Matthew J. Ferber, PhD                                                                                                                                                                                                     
Director, Clinical Genome Sequencing Laboratory                                                                                                                                                           
Consultant, Laboratory Medicine and Pathology                                                                                                                                                                         
Mayo Clinic, Rochester

Teresa Kruisselbrink is a Licensed Certified Genetic Counselor, supervisor, and co-director for the Genomics in Action Strategic Initiative in the Center for Individualized Medicine at Mayo Clinic in Rochester, MN. She and her team collaborate to discover, translate and apply new individualized medicine tools and services across the three sites of the Mayo Clinic enterprise.

Konstantinos Lazaridis, M.D., serves as the Carlson and Nelson Endowed Executive Director, Mayo Clinic Center for Individualized Medicine. Dr. Lazaridis is a consultant in the Division of Gastroenterology and Hepatology, Department of Internal Medicine at Mayo Clinic, with a joint appointment in the Department of Clinical Genomics.

Matthew Ferber, PhD, is a Consultant in the Department of Laboratory Medicine and Pathology, and a CEO of sorts for Mayo Clinic GeneGuide, the interpretive engine for the Tapestry program and beyond. He has a real passion for bringing the benefits of genomic medicine to patients around the world.

Tapestry is a Mayo Clinic research study, which includes receiving genetic sequencing data from Helix, up to the full whole exome dataset. The goal of this study is to provide: (i) an immediate interpretation of ancestry/genealogy and several non-disease traits, as well as, clinically actionable variants for an inherited form of high cholesterol called familial hypercholesterolemia (FH), breast and ovarian cancer (HBOC), and Lynch syndrome to each participant; (ii) an additional subset of focused clinically actionable genetic findings, such as, certain types of hereditary cancers, hereditary heart conditions and severe responses to certain medications, will be returned to the provider and to the participant, via the provider, genetic counselor consultation, and/or Mayo Clinic research interpretation; (iii) storing of genomic and phenotypic data for future research analysis.

LEARNING OBJECTIVES
Upon conclusion of this activity, learners should be able to:

•Define the clinical and research aims of the Tapestry Study
•Describe the unique participant invitation and consenting process
•Review outcomes and patient impact of actionable results
•Summarize research opportunities through access to Tapestry data


ATTENDANCE / CREDIT
Text the session code (provided only at the session) to 507-200-3010 within 48 hours of the live presentation to record attendance. All learners are encouraged to text attendance regardless of credit needs. This number is only used for receiving text messages related to tracking attendance. Additional tasks to obtain credit may be required based on the specific activity requirements and will be announced accordingly. Swiping your badge will not provide credit; that process is only applicable to meet GME requirements for Residents & Fellows.

TRANSCRIPT
Any credit or attendance awarded from this session will appear on your Transcript.

For disclosure information regarding Mayo Clinic School of Continuous Professional Development accreditation review committee member(s) and staff, please go here to review disclosures.

QUESTIONS?
Contact Coordinator Chris Scott 507-284-0426

Presenter: 
Teresa M. Kruisselbrink, MS, CGC
Co-presenter: 
Konstantinos N. Lazaridis, MD
Additional presenter: 
Matthew J. Ferber, PhD (Moderator)
Where did the idea for the course originate?: 
Minnesota
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Where did the idea for the course originate?: 
Minnesota