Mayo Clinic Talks: All Age-Related Changes May Not Be Inevitable: Senescent Cells and Anti-Aging

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Host: Darryl S. Chutka, M.D.


Guest: Nathan K. LeBrasseur, Ph.D., M.S.

The effects of aging occur in all our organs. In muscles, there is a reduction in strength and stamina; the brain shows a decrease in cognitive function and the ability to learn new information. Aging causes a reduced ability of the liver to metabolize drugs and the kidney’s ability to eliminate various waste products. Our guest for this podcast is aging researcher Nathan K. LeBrasseur, Ph.D., M.S., the senior author of a study recently published in the journal “Aging Cell.” The authors described significant benefits from exercise on a cellular level which correlated with an improvement in physical changes related to aging. We’ll discuss cellular changes which occur with aging, the significance of senescent cells and how exercise can reduce the impact of aging on both a cellular level as well as clinically.

Specific topics:

  • The effects of aging on a cellular level
  • Variability in the rate of aging in individuals
  • Function of senescent cells
  • Effects of exercise on senescent cells
  • Clinical correlations resulting from the elimination of senescent cells
  • Recommendations clinicians can give their patients to reduce the effects of aging

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Target Audience

This course is intended for primary care providers: physicians, nurse practitioners, and physician assistants

Learning Objectives

Mayo Clinic Talks Podcasts Learning Objectives

Participation in this Mayo Clinic online course does not indicate nor guarantee competence or proficiency in the performance of any procedures which may be discussed or taught in this course.

Course summary
Available credit: 
  • 0.25 AMA PRA Category 1 Credit
  • 0.25 Attendance
Course opens: 
Course expires: 

Accreditation Statement
In support of improving patient care, Mayo Clinic College of Medicine and Science is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Credit Statement(s):


Mayo Clinic College of Medicine and Science designates this enduring material for a maximum of .25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

For disclosure information regarding Mayo Clinic School of Continuous Professional Development accreditation review committee member(s), please go here to review disclosures.

Available Credit

  • 0.25 AMA PRA Category 1 Credit
  • 0.25 Attendance


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