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Mayo Clinic Talks Episode 245: Watching Out for Loperamide Abuse

Mayo Clinic Talks

Mayo Clinic Talks Podcast

Episode 245: Watching Out for Loperamide Abuse

Registration required for CME credit


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Recorded February, 2021

Tyler S. Oesterle, M.D., M.P.H.

Opioid abuse remains a significant problem, and as law enforcement and regulatory agencies tighten access to prescription analgesics, individuals are seeking alternatives. It’s been discovered that when taken at very high doses, loperamide can produce similar effects to the opioid analgesics and the drug is inexpensive when compared to the price of both illicit and prescription opioids. As a result, loperamide abuse has become a significant problem. In this episode we discuss loperamide abuse with Tyler Oesterle, M.D., M.P.H., a psychiatrist at Mayo Clinic’s Rochester campus. We’ll review the typical central nervous system effects of high dose loperamide and the associated safety issues.

Specific topics:
•    Current status of the opioid crisis in the U.S.
•    Effects of loperamide in both therapeutic and excessive doses
•    Reasons behind taking high dose loperamide in excessive doses
•    Safety issues associated with high dose loperamide
•    Potential of high dose loperamide leading to drug dependence

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Target Audience

This course is intended for primary care providers: physicians, nurse practitioners, and physician assistants

Learning Objectives

Upon completion of the Mayo Clinic Talks Podcast course, learners should be able to:

  • Describe the current treatment recommendations for patients with hyperlipidemia.
  • List the various categories of hypertension.
  • Describe the current pharmacologic treatment available for patients with osteoporosis.

Participation in this Mayo Clinic online course does not indicate nor guarantee competence or proficiency in the performance of any procedures which may be discussed or taught in this course.

Course summary
Available credit: 
  • 0.25 AMA PRA Category 1 Credit
  • 0.25 Attendance
Course opens: 
Course expires: 

Accreditation Statement
In support of improving patient care, Mayo Clinic College of Medicine and Science is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Credit Statement(s):


Mayo Clinic College of Medicine and Science designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

For disclosure information regarding Mayo Clinic School of Continuous Professional Development accreditation review committee member(s), please go here to review disclosures.

Available Credit

  • 0.25 AMA PRA Category 1 Credit
  • 0.25 Attendance


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