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ForwardNEPHROGENETICS Update 2026: Integrating Genetics into Clinical Practice
This course offers Live (in-person) and Livestream (virtual) attendance options
Course Directors: Fouad T. Chebib, M.D. and Silvia M. Titan, M.D., Ph.D.
Genetics is rapidly transforming clinical practice in nephrology with innovations in diagnosis, prognostication, biomarkers, and therapeutic targets. There is an urgent need to train the nephrology workforce and offer periodic learning opportunities in the constant evolving landscape of genetics, thereby capacitating providers to promote refined diagnosis and personalized medicine in clinical practice. This course aims to provide the audience with an in-depth review of current knowledge on genetics of monogenic and complex renal diseases.
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Registration Fee(s) | |
M.D., D.O., Ph.D. | $595 |
Allied Health, NP, PA, Retirees | $595 |
Target Audience
This course is designed for nephrologists, nephrology fellows, and other clinicians involved in the care of patients with kidney disease. It is also highly relevant for clinical geneticists, genetic counselors, and transplant specialists seeking to integrate genomic insights into practice. Advanced practice providers, including nurse practitioners and physician assistants in nephrology, will benefit from the practical, case-based approach. Pathologists and laboratory medicine professionals involved in genetic testing and interpretation are also encouraged to attend. The content is best suited for learners with an intermediate to advanced understanding of nephrology and an interest in precision medicine.
Learning Objectives
Upon completion of this activity, participants should be able to:
- Identify clinical indications and patient populations in nephrology for which genotyping is appropriate and clinically impactful.
- Assess the role of genotyping in refining diagnosis and prognostication in inherited and monogenic kidney diseases, including polycystic kidney disease (PKD), autosomal dominant tubulointerstitial kidney disease (ADTKD), COL4-related kidney diseases, Fabry disease, monogenic nephrotic syndrome, nephrolithiasis, and complement-mediated kidney disorders.
- Apply genotyping results to guide therapeutic decision-making and individualized treatment strategies in patients with genetic kidney diseases.
- Compare commercially available genetic testing modalities used in nephrology with respect to test methodology, diagnostic yield, limitations, and appropriate clinical use.
- Determine when additional genetic analyses or functional testing are indicated following initial genotyping.
- Integrate genetic testing principles into clinical practice through analysis of case-based scenarios involving patients with suspected or confirmed genetic kidney disease.
Attendance at any Mayo Clinic course does not indicate or guarantee competence or proficiency in the skills, knowledge or performance of any care or procedure(s) which may be discussed or taught in this course.
7:00AM | Registration, Breakfast and Exhibits |
7:45 AM | Welcome Announcements, Introductions, & Pretest |
Session I - Cystic Kidney Diseases, Precision Medicine into practice! Moderators: Peter C. Harris, PH.D., & Silvia M. Titan, M.D., Ph. D. | |
8:00 AM | How Genotyping Transformed the Landscape of Cystic Kidney Disease Neera K. Dahl, M.D., Ph.D.– Mayo Clinic Minnesota |
8:30 AM | Cystic Kidney Diseases in Practice: Genetic Architecture, Imaging, and Risk Stratification Fouad T. Chebib, M.D. – Mayo Clinic Florida |
9:00 AM | Polycystic Liver Disease Genotype Phenotype Correlations and Implications for Treatment Marie C. Hogan, M.D., Ph.D. – Mayo Clinic Minnesota |
9:30 AM | Q & A / Discussion Panel: Neera K. Dahl, M.D., Ph.D., Fouad T. Chebib, M.D., Marie C. Hogan, M.D., Ph.D. |
9:45 AM | Break & Exhibits |
Session II - Challenges and VUS in Genetic Testing Moderators: Marie C. Hogan, M.D., Ph.D. & R John Presutti, D.O., FAAFP | |
10:00 AM | Diagnostic Dilemmas in Nephrogenetics: Case Based Insights from Panels to Whole Genome Sequencing Peter C. Harris, PH.D. – Mayo Clinic Minnesota |
10:30 AM | Variant Interpretation and Challenges with Uncertainties Filippo Pinto e Vairo, M.D., Ph.D. – Mayo Clinic Minnesota |
11:00 AM | Characterizing Genetic Variants Through Functional Testing Laura J. Lambert, Ph.D. – Mayo Clinic Minnesota |
11:30 AM | Q & A / Discussion Panel: Peter C. Harris, Ph.D., Filippo Pinto e Vairo, M.D., Ph.D., Laura J. Lambert, Ph.D. |
11:45 AM | Exhibits |
12:00 PM | OPTIONAL Lunch with TBD |
12:45 PM | Exhibits & Poster Abstracts |
Session III – The Other Side: What is Behind my Ordering Test Moderators: Michael A. Mao, M.D., & Ibrahim Khambati, M.D., M.B.A. | |
1:00 PM | Genetic Testing in Clinical Practice – A Laboratory Perspective Ann M. Moyer, M.D., Ph.D. - Mayo Clinic Minnesota |
1:30 PM | Genetics and Kidney Tissue Matthew G. Sampson, M.D. - Boston Children’s Hospital. MA, USA |
2:00 PM | Integrating Genetic Testing and Genetic Counseling into Contemporary Nephrology Practice Joan M. Steyermark, M.S., CGC, & Laura C. Duncan, M.S., CGC- Mayo Clinic |
2:25 PM | Practical Implementation of Genetic Testing in Modern Nephrology Practice Ibrahim Khambati, M.D., M.B.A. – Mayo Clinic Florida |
2:45 PM | Q & A / Discussion Panel: Ann M. Moyer, M.D., Ph.D., Matthew G. Sampson, M.D., & Joan M. Steyermark, M.S., CGC, Laura C. Duncan, M.S., Ibrahim Khambati, M.D., M.B.A. |
3:00 PM | Break & Exhibits |
Session IV – Genetics in Glomerular Diseases Moderators: Rose Mary Attieh, M.D & Ann M. Moyer, M.D., Ph.D. | |
3:15 PM | Alport Syndrome: From Nomenclature to Prognosis and Treatment Moumita Barua, M.D., - University of Toronto, Canada |
3:45 PM | Genetics of Primary Podocytopathies: Insights into Pathophysiology and Treatment. Rasheed Gbadegesin, M.D., Duke University, NC-USA. |
4:15 PM | Fabry’s Disease: What a Nephrologist Needs to Know Anjay Rastogi, M.D. - Division of Nephrology, UCLA, CA-USA. |
4:45 PM | Q & A / Discussion Panel: Moumita Barua, M.D., Rasheed Gbadegesin, M.D., & Anjay Rastogi, M.D. |
5:00 PM | Announcements/Adjourn |
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Saturday, December 5 | |
7:00 AM | Registration, Breakfast and Exhibits |
7:55 AM | 1st Day Overview & Announcements |
Session V – Genes Determining with Multiple Phenotypes Moderators: Hani M. Wadei, M.D. & Mira T. Keddis, M.D. | |
8:00 AM | Genetics of Complement Disorders Anuja Java, M.D., - Washington University School of Medicine, St. Louis, MO, USA. |
8:30 AM | Integrating APOL1 Testing into Clinical Practice Opeyemi Olabisi, M.D., - Duke University, NC-USA |
9:00 AM | Genetic Testing in Kidney Transplant Mireille El Ters, M.D., – Mayo Clinic Minnesota |
9:30 AM | Q & A / Discussion Panel: Anuja Java, M.D., Opeyemi Olabisi, M.D., Mireille El Ters, M.D., |
9:45 AM | Break & Exhibits |
Session VI – Beyond Monogenic Diseases Moderators: Shane A. Bobart M.D. & Neera K. Dahl, M.D., Ph.D. | |
10:00 AM | Advances and Challenges of Defining Penetrance in NephroGenetics Alex Chang, M.D., - Geisinger, MA-USA. |
10:30 AM | Searching for Genes: GWAS and Burden Tests in Nephrology Silvia M. Titan, M.D., Ph.D., – Mayo Clinic Minnesota |
11:00 AM | Use of Polygenic Scores in Complex Diseases and Phenotypes Krzysztof Kiryluk, M.D., - Columbia University, NY – USA. |
11:30 AM | Q & A / Discussion Panel: Alex Chang, M.D., Krzysztof Kiryluk, M.D., & Silvia M. Titan, M.D., Ph.D. |
11:45 AM | Exhibits |
12:00 PM | OPTIONAL Lunch with TBD |
12:45 PM | Exhibits & Poster Abstracts |
Session VII – Nephrolithiasis and Tubulopathies Moderators: Moumita Barua, M.D., & Ivan E. Porter II, M.D. | |
1:00 PM | Primary Hyperoxaluria: Treating the Genes John C. Lieske, M.D. - Mayo Clinic Minnesota |
1:30 PM | Genetics of Nephrolithiasis Mira T. Keddis, M.D. – Mayo Clinic Arizona |
2:00 PM | Gene Therapy to Nephronophthisis Friedhelm Hildebrandt, M.D. - Children’s Hospital, Boston, MA - USA |
2:30 PM | Advances in ADTKD Kai-Uwe Eckhardt, M.D. - Charite Universitatsmedizin, Germany |
3:00 PM | Q & A / Discussion Panel: John C. Lieske, M.D., Mira T. Keddis, M.D., Friedhelm Hildebrandt, M.D., Kai-Uwe Eckhardt, M.D. |
3:15 PM | Closing Remarks/Adjourn |
Hotel Booking information will be available shortly. Please check back soon!
All travel and lodging expenses are the sole responsibility of the individual registrant.
Accreditation Statement
In support of improving patient care, Mayo Clinic College of Medicine and Science is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.
AMA
Mayo Clinic College of Medicine and Science designates this live activity for a maximum of 13.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
AAPA
Mayo Clinic College of Medicine and Science has been authorized by the American Academy of Physician Associates (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 13.25 AAPA Category 1 CME credits. PAs should only claim credit commensurate with the extent of their participation.
ANCC
Mayo Clinic College of Medicine and Science designates this activity for a maximum of 13.25 ANCC contact hours. Nurses should claim only the credit commensurate with the extent of their participation in the activity.
IPCE
This activity was planned by and for the healthcare team, and learners will receive 13.25 Interprofessional Continuing Education (IPCE) credit for learning and change.
Additional Credit Statements to be placed on your course
Other Healthcare Professionals:
A record of attendance will be provided to all registrants for requesting credits in accordance with state nursing boards, specialty societies or other professional associations.Day:
| Day: | Credits: |
| Friday | 7.50 |
| Saturday | 5.75 |
For disclosure information regarding Mayo Clinic School of Continuous Professional Development accreditation review committee member(s) and staff, please go here to review disclosures.
Available Credit
- 13.25 AAPA Category 1
- 13.25 AMA PRA Category 1 Credit™
- 13.25 ANCC
- 13.25 Attendance
- 13.25 IPCE
To exhibit at this activity please complete and submit the Exhibit Agreement Form below. Exhibit Space availability is based on the order completed forms are submitted until space runs out.
Exhibit space is not confirmed until the submitting representative is notified of their confirmation by a member of the Mayo Clinic School of Continuous Professional Development.
PROSPECTUS: View the prospectus to see available Exhibit and Sponsorship opportunities and complete the Letter of Agreement to request your space.
To see the course fee, please log in or create an account
Registration Fee(s) | |
M.D., D.O., Ph.D. | $595 |
Allied Health, NP, PA, Retirees | $595 |
Before registering, please update your profile.
To claim credit for livestream participation in this course, learners must view the content during the hours posted for the live activity. This course is not approved for on-demand delivery.
Commitment to Belonging and Inclusion
Mayo Clinic School of Continuous Professional Development (MCSCPD) strives to foster a learning environment in which all individuals are valued, allowing all to achieve their fullest potential.
Every effort will be made to accommodate dietary requirements; however, some requests may not be feasible based on venue kitchen capabilities. Attendees will be contacted in advance if a dietary restriction cannot be fulfilled.
The Mayo Clinic School of Continuous Professional Development strives for fully accessible learning experiences. If you anticipate any barriers while attending this course, please reach out to the course coordinator who will be in touch with all registrants. If you need disability-related accommodations, please contact the Office of Wellness and Academic Support – Disability Access Services at MCCMS.DS@mayo.edu.
Cancellation and Refund Policy
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