46th Annual Practice of Internal Medicine
This course offers Live (in-person) and Livestream (virtual) attendance options

Course Directors: Brandon P. Verdoorn, M.D., and Hannah C. Nordhues, M.D.
May 11 - 15, 2026 - Hilton Rochester Mayo Clinic Area - Rochester, Minnesota
Practice of Internal Medicine is a postgraduate course offering internists and primary care professionals a state-of-the-art update. Mayo Clinic faculty present lectures on common clinical problems across gastroenterology, infectious diseases, rheumatology, geriatrics, emergency medicine, cardiology, neurology, endocrinology, pulmonary, and women’s health.
To see the course fee, please log in or create an account
| Registration Fee(s) | |
|---|---|
| M.D., D.O., Ph.D. | $950 |
| Allied Health, NP, PA, Retirees | $900 |
Target Audience
This course is designed for general internists, internal medicine subspecialists, family medicine physicians, and other primary healthcare professionals.
Learning Objectives
Upon completion of this activity, participants should be able to:
- Describe the current approach to diagnosis and treatment of MASLD.
- Outline treatment options for Alzheimer’s Disease in 2026.
- Advise patients on breast cancer screening, balancing risks and benefits and incorporating society guidelines.
Attendance at any Mayo Clinic course does not indicate or guarantee competence or proficiency in the skills, knowledge or performance of any care or procedure(s) which may be discussed or taught in this course.
Monday, May 11, 2026 | |
6:45 a.m. | Registration & Breakfast |
7:45 a.m.
| Welcome and Course Overview |
8:00 a.m.
| The Eye in Primary Care |
8:35 a.m.
| The Ups and Downs of Recurrent Emesis: Cyclical Vomiting Syndrome and Cannabis Hyperemesis |
9:10 a.m.
| All About GLP-1’s: Indications, Side Effects, and Benefits |
9:45 a.m. | Break |
10:05 a.m.
| Is This Hard on My Kidneys? |
10:40 a.m.
| Cases in COPD |
11:15 a.m.
| Clinical Pearls – Gastroenterology |
11:55 a.m. | Lunch Break |
1:00 p.m.
| Depression in Primary Care: Diagnosis and Management Options |
1:35 p.m.
| Medical Cannabis and CBD Products in Older Adults |
2:10 p.m. | Break |
2:30 p.m.
| Nocturnal Leg Cramps: Management for the Generalist |
3:05 p.m.
| Cases in HFpEF and GDM Therapy |
3:40 p.m. | Monday Highlights |
3:45 p.m. | Adjourn |
Tuesday, May 12, 2026 | |
7:00 a.m. | Breakfast |
7:55 a.m.
| Daily Overview |
8:00 a.m.
| Breast Disease and Screening in 2026 |
8:35 a.m.
| Chest Pain and Palpitations |
9:10 a.m.
| Memory Problems: What to Ask, When to Worry, and What to Do |
9:45 a.m. | Break |
10:05 a.m.
| Practice Changing Updates in Primary Care |
10:40 a.m.
| Primary Care for Solid Organ Transplant Recipients |
11:15 a.m.
| Clinical Pearls - General Internal Medicine |
11:55 a.m. | Lunch Break |
1:00 p.m.
| Rheumatology Curbside Consults |
1:35 p.m.
| Hypercalcemia: Diagnosis, Management, and Pitfalls in Primary Care |
2:10 p.m. | Break |
2:30 p.m.
| Cases in VTE, from Simple to Complex |
3:05 p.m.
| Cases from the Women’s Health Clinic |
3:40 p.m. | Tuesday Highlights |
3:45 p.m. | Adjourn |
Wednesday, May 13, 2026 | |
7:00 a.m. | Breakfast |
7:55 a.m.
| Daily Overview |
8:00 a.m.
| Sports Medicine for the Generalist |
8:35 a.m.
| Diagnosis and Treatment of MASLD in Primary Care |
9:10 a.m.
| Quick Office CBT for Uncertain Times |
9:45 a.m. | Break |
10:05 a.m.
| Adrenal Insufficiency – What PCPs Need to Know |
10:40 a.m.
| Clinical Pearls – Neurology |
11:15 a.m.
| Clinical Pearls – Addiction Medicine |
11:55 a.m. | Lunch Break |
1:00 p.m.
| Updates on Multiple Sclerosis Diagnosis and Management |
1:35 p.m.
| Radiation Therapy for Benign Conditions: What’s New |
2:10 p.m. | Break |
2:30 p.m.
| Common Cosmetic Dermatology Concerns for the Internist |
3:05 p.m.
| Chest Pain and Palpitations |
3:40 p.m. | Wednesday Highlights |
3:45 p.m. | Adjourn |
Thursday, May 14, 2026 | |
7:00 a.m. | Breakfast |
7:55 a.m.
| Daily Overview |
8:00 a.m.
| Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
8:35 a.m.
| Approach to Insomnia |
9:10 a.m.
| Updates on Personal Health Devices and Apps Patients Use |
9:45 a.m. | Break |
10:05 a.m.
| Hereditary Cancer Syndromes |
10:40 a.m.
| Primary Care of the BMT Patient |
11:15 a.m.
| MGUS and Dysproteinemias |
11:55 a.m. | Lunch Break |
1:00 p.m.
| Primary Care of the Patient with Advanced CKD |
1:35 p.m.
| Updates in Cervical Cancer Screening: Primary HPV, Self-Collection, and More |
2:10 p.m. | Break |
2:30 p.m.
| Updates in Alzheimer’s Disease Treatment – Where Are We in 2026 |
3:05 p.m.
| Approach to Breast Pain |
3:40 p.m. | Wednesday Highlights |
3:45 p.m. | Adjourn |
Friday, May 15, 2026 | |
7:00 a.m. | Breakfast |
7:55 a.m.
| Daily Overview |
8:00 a.m.
| Approach to Falls in Older Adults |
8:35 a.m.
| Management of Common Painful Spine Conditions: Neck Pain, Back Pain, Radiculopathy |
9:10 a.m.
| An Update on H. Pylori: Diagnosis and Management |
9:45 a.m. | Break |
10:05 a.m.
| Controversies in Advance Care Planning: Can We Just Stop Doing ACP Now? |
10:40 a.m.
| Systemic Lupus Erythematosus |
11:15 a.m.
| Pharmacotherapy for Alcohol Use Disorder |
11:50 a.m.
| Wrap-Up and Closing Remarks |
12:00 p.m. | Adjourn |
Lodging Accommodations
A limited number of guest rooms have been reserved for attendees and their guests with special course rates at the following downtown Rochester hotel. In order to receive the special rate (plus applicable taxes and fees), reservations must be made before the room block is filled or before the cutoff date of April 19, 2026, whichever comes first. After April 19, 2026, reservations will be taken based on space and rate availability. Please identify yourself as a participant of the 2026 Mayo Clinic Annual Practice of Internal Medicine (POIM) when making your reservation.
Mayo Clinic Annual Practice of Internal Medicine - Hilton Rochester
10 East Center Street, Rochester, MN 55904
507-258-5757
Rate: $279/night (standard room)
$20/day self-parking (*Subject to change)
$34/day valet parking
Travel
Rochester, Minnesota is a friendly city that greets thousands of visitors from around the world each year. The city is serviced by a modern international airport with multiple flights daily via American and Delta Airlines. Access to and from the airport is provided by taxi, shuttle service, and rental car. The airport is located approximately 10 miles from the Hilton Rochester Mayo Clinic Area and the Mayo Clinic campus.
Note to Travelers: Several cities in the United States are named Rochester. When you make airline reservations and check your baggage, be sure that your destination is Rochester, Minnesota (RST) and that your baggage has been properly tagged. Flying through the Minneapolis/St. Paul International Airport (MSP) is another option. The following shuttle services offer multiple trips daily. Travel time is approximately 75 minutes.
Groome Transportation
507-280-9270
Rates beginning at $50 per person*
Rochester Shuttle Service
507-216-6354
Rates beginning at $49 per person*
*Rates are quoted for one-way fares to or from the Minneapolis Airport. Rates are subject to change and do not include taxes, fee, or gratuities.
Travel arrangements and expenses are the sole responsibility of the individual registrant.
You may wish to visit Experience Rochester website for additional travel information, accommodation options, and area information.
PARKING
Parking is available in hotel and city ramps. The cost for parking is not included in the registration fee; parking will not be validated.
All travel and lodging expenses are the sole responsibility of the individual registrant.
Accreditation Statement
In support of improving patient care, Mayo Clinic College of Medicine and Science is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.
Credit Statement(s):
AMA
Mayo Clinic College of Medicine and Science designates this live activity for a maximum of 27.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
AAPA
Mayo Clinic College of Medicine and Science has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 27.75 AAPA Category 1 CME credits. PAs should only claim credit commensurate with the extent of their participation.
ANCC
Mayo Clinic College of Medicine and Science designates this activity for a maximum of 27.75 ANCC contact hours. Nurses should claim only the credit commensurate with the extent of their participation in the activity.
Other Healthcare Professionals:
A record of attendance will be provided to all registrants for requesting credits in accordance with state nursing boards, specialty societies or other professional associations.
| Day | Credit(s) |
|---|---|
| Monday | 6.00 |
| Tuesday | 6.00 |
| Wednesday | 6.00 |
| Thursday | 6.00 |
| Friday | 3.75 |
For disclosure information regarding Mayo Clinic School of Continuous Professional Development accreditation review committee member(s) and staff, please go here to review disclosures.
Available Credit
- 27.75 AAPA Category 1
- 27.75 AMA PRA Category 1 Credit™
- 27.75 ANCC
- 27.75 Attendance
Thank you for your interest in 46th Annual Practice of Internal Medicine. This course is currently in the early planning stages. If you’d like to be notified when opportunities become available, please add your name to our Notify Me list. Signing up to be notified will ensure that you receive an email when exhibitor information is available. No additional information is available until then.
To see the course fee, please log in or create an account
| Registration Fee(s) | |
|---|---|
| M.D., D.O., Ph.D. | $950 |
| Allied Health, NP, PA, Retirees | $900 |
Please update your profile to let us know if you have dietary restrictions or access requirements.
To claim credit for livestream participation in this course, learners must view the content during the hours posted for the live activity. This course is not approved for on-demand delivery.
Commitment to Belonging and Inclusion
Mayo Clinic School of Continuous Professional Development (MCSCPD) strives to foster a learning environment in which all individuals are valued, allowing all to achieve their fullest potential.
Cancellation and Refund Policy
View Cancellation and Refund Policy
All requests must be submitted in writing using the Contact Us Form.
Any use of this site constitutes your agreement to the Terms and Conditions of Registration.

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