March 1-5, 2027 - The Royal Sonesta Kaua'i Resort – Lihue, Hawaii

This course offers Live (in-person) and Livestream (virtual) attendance options

The Mayo Clinic Sleep Medicine Update course is conducted by Mayo Clinic sleep researchers and clinicians. This course reviews the latest advances in practice and research using case-based scenarios enriched with personal clinical experiences. The course is designed to provide attendees with a comprehensive review of sleep disorders and practical steps to enhance clinical skills and practice.

April 2-3, 2027 - Ritz-Carlton - Rancho Mirage, California

This course offers Live (in-person) and Livestream (virtual) attendance options

Discover how emerging science is reshaping GI cancer care. Expert faculty will highlight breakthroughs in targeted therapy, immunotherapy, radiopharmaceuticals, molecular profiling, transplant strategies, and precision oncology across pancreatic, hepatobiliary, gastroesophageal, neuroendocrine, and colorectal cancers. Expert faculty will examine innovative approaches to precision oncology, including next-generation radionuclide therapies for neuroendocrine tumors, the expanding role of RAS inhibition and molecularly targeted treatments in pancreatic cancer, and strategies for integrating biomarker-driven therapies earlier in the disease course. Participants will explore contemporary management of hepatocellular carcinoma, including transplant candidacy, downstaging approaches, perioperative treatment considerations, and the integration of systemic and locoregional therapies. Additional sessions will address advances in biliary tract cancers, including FGFR2-targeted therapies and perioperative management, as well as emerging therapeutic targets in gastric and esophageal cancers such as HER2, CLDN18.2, and immunotherapy-based approaches. The activity will also highlight the growing clinical relevance of tumor spatial architecture, organ preservation strategies, measurable residual disease (MRD), and molecular characterization in treatment selection. .

May 13 - 15, 2027 - Mayo Clinic - Rochester, Minnesota

This course offers Live (in-person) and Livestream (virtual) attendance options

Mayo Clinic's 29th Edition “Teach the Teachers” Advanced Elbow Surgical Skills Course Forge the Future: Instability is an advanced level course designed for orthopedic surgeons with a special interest in upper extremity trauma, elbow surgery and trauma surgery. The course provides technical skills orientation, with the didactic portions limited to the necessary introductions and theoretical knowledge required for the technical components. Live surgical broadcasts used during lecture sessions demonstrate surgical techniques pertaining to this year's topic of elbow instability as well as other areas of elbow orthopedics.

General Session: April 29 - May 1, 2027 - JW Marriott Tucson Starr Pass Resort & Spa - Tucson, Arizona

Special Feature: Pediatric Palliative Cases (Pre-Course Session Day) April 28, 2027. This course offers Live (in-person) and Livestream (virtual) attendance options

Mayo Clinic's Updates in Palliative Care is a multidisciplinary CME course designed to build and enhance your palliative care knowledge. Experts from Mayo Clinic provide clinically relevant pearls for palliative care providers and clinicians from primary care, hematology/oncology, hospital medicine, critical care, pediatrics, and related specialties. If you care for patients with serious illness and are looking to broaden your skills beyond the basics, this is the course for you.

March 5th - 7th, 2027 - Mayo Clinic - Phoenix, Arizona

This course offers Live (in-person) and Livestream (virtual) attendance options

The Mayo Clinic Headache Symposium is designed to equip healthcare professionals with the knowledge and skills to diagnose, manage, and treat primary and secondary headache disorders, including migraine. Attendees explore various headache pathologies through engaging lectures, expert panel discussions, and interactive question and answer sessions. This symposium features an interactive workshop that consists of hands-on injection training and cadaver anatomy review.

October 8-9, 2027 - Mayo Civic Center - Rochester, Minnesota

This course offers Live (in-person) and Livestream (virtual) attendance options

The 35th Biennial Dermatology Symposium: The O’Leary Meeting 2027 aims to visit challenging cases in dermatology and share emerging diagnostics and therapeutics in bread and butter, multi-disciplinary , and cosmetic dermatological conditions. The updates are appropriate for the dermatologist and dermatological team. The 2027 meeting highlights world renowned speakers in their fields.

December 4 - 5, 2026 - Mayo Clinic - Jacksonville, Florida

This course offers Live (in-person) and Livestream (virtual) attendance options

Genetics is rapidly transforming clinical practice in nephrology with innovations in diagnosis, prognostication, biomarkers, and therapeutic targets. There is an urgent need to train the nephrology workforce and offer periodic learning opportunities in the constant evolving landscape of genetics, thereby capacitating providers to promote refined diagnosis and personalized medicine in clinical practice. This course aims to provide the audience with an in-depth review of current knowledge on genetics of monogenic and complex renal diseases.